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钾缺乏大鼠的磷代谢

Phosphorus metabolism in potassium-deficient rats.

作者信息

Freeman R M, Lawton W J

出版信息

Am J Clin Nutr. 1977 Apr;30(4):549-51. doi: 10.1093/ajcn/30.4.549.

DOI:10.1093/ajcn/30.4.549
PMID:851083
Abstract

Hypophosphatemia as a consequence of potassium deficiency has been reported sporadically. Most cases have been complicated by other factors which might lead to decreased serum phosphorus levels. Therefore, the serum phosphorus in this study was measured in Sprague-Dawley rats with nutritionally induced potassium deficiency. Severe potassium depletion was manifested by hypokalemia (2.4 mEq/liter versus 3.9 mEq/liter in controls) and decreased muscle potassium content. Statistically significant hypophosphatemia did not develop, although decreased muscle phosphorus content was observed. Therefore, hypophosphatemia is not a regular accompaniment of severe potassium deficiency in the rat.

摘要

有零星报道称低钾血症可导致低磷血症。大多数病例都伴有其他可能导致血清磷水平降低的因素。因此,本研究对营养性低钾血症的斯普拉格-道利大鼠的血清磷进行了测量。严重的钾缺乏表现为低钾血症(对照组为3.9 mEq/升,低钾血症组为2.4 mEq/升)以及肌肉钾含量降低。尽管观察到肌肉磷含量降低,但并未出现具有统计学意义的低磷血症。因此,低磷血症并非大鼠严重低钾血症的常见伴随症状。

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