Arnauld J, Lachance P A
J Nutr. 1980 Dec;110(12):2480-9. doi: 10.1093/jn/110.12.2480.
In rat muscle, a depletion of potassium is partially compensated for by a gain of sodium. In addition cationic (free basic) amino acids accumulate in the muscle of the potassium-deficient rat. A 31% muscle potassium depletion was induced by dietary restriction of potassium in two groups of rats which differed in the test diet content of lysine and arginine (adequate and excessive). The excess lysine and arginine accumulation in the muscle of the rats fed excess levels of lysine and arginine was accompanied by an equimolar reduction in the gain of sodium. The results demonstrate that lysine and arginine accumulation consists of a transfer of positive charges in compensation to the charges lost with potassium, and that cationic amino acids may spare the role of sodium under these conditions.
在大鼠肌肉中，钾的耗竭部分地由钠的增加来补偿。此外，阳离子（游离碱）氨基酸在缺钾大鼠的肌肉中积累。通过对两组大鼠进行钾的饮食限制来诱导31%的肌肉钾耗竭，这两组大鼠的试验饮食中赖氨酸和精氨酸的含量不同（充足和过量）。在摄入过量赖氨酸和精氨酸的大鼠肌肉中，过量的赖氨酸和精氨酸积累伴随着钠增加量的等摩尔减少。结果表明，赖氨酸和精氨酸的积累包括正电荷的转移，以补偿随钾流失的电荷，并且在这些条件下阳离子氨基酸可能替代钠的作用。
