al-Hazzaa S A, Green W R, Mann R B
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Ophthalmology. 1993 Jun;100(6):961-5. doi: 10.1016/s0161-6420(93)31548-4.
Angiotropic large cell lymphoma is a rare, generally fatal disease characterized by multifocal proliferation of neoplastic mononuclear cells within the lumens of blood vessels.
The authors report the clinical and immunohistochemical features of four patients with angiotropic large cell lymphoma.
All patients presented with central nervous system symptoms, and three of the four had fever of unknown origin and anemia. The diagnosis was established by postmortem examination of the eyes in four patients and additionally by autopsy in three of the four patients. Two of the three autopsied patients had rare foci of extravascular involvement. One patient had erythrophagocytosis. Immunohistochemical stains on paraffin-embedded sections confirmed the diagnosis of lymphoma in all four patients.
The results of this study support the B-cell lymphocyte origin of angiotropic large cell lymphoma.
血管中心性大细胞淋巴瘤是一种罕见的、通常致命的疾病，其特征为肿瘤性单核细胞在血管腔内多灶性增殖。
作者报告了4例血管中心性大细胞淋巴瘤患者的临床和免疫组化特征。
所有患者均有中枢神经系统症状，4例中有3例伴有不明原因发热和贫血。4例患者经眼部尸检确诊，其中3例还进行了尸检。3例接受尸检的患者中有2例有罕见的血管外受累病灶。1例患者有噬红细胞现象。石蜡包埋切片的免疫组化染色证实所有4例患者均为淋巴瘤。
本研究结果支持血管中心性大细胞淋巴瘤起源于B淋巴细胞。
