Lopez-Novoa J M, Rengel M A
Am J Physiol. 1977 Apr;232(4):F315-8. doi: 10.1152/ajprenal.1977.232.4.F315.
The object of this study was to localize increased sodium resorption in rats with chronic hepatic cirrhosis. Cirrhosis was induced by the administration of phenobarbital and carbon tetrachloride. The animals retained salt and water after loading and showed edema and ascites. Salt and water balance, clearance, and micropuncture tests were performed. Five or six weeks after the start of procedures to induce injury, the rats were unable to excrete salt and water loads promptly. Urine flow and sodium concentration were significantly less in cirrhotic rats with edema and ascites than in the normal controls. The glomerular filtration rate was slightly lower in the right, nonmicropunctured kidney but was the same in the left. The nephron glomerular filtration rates of surface nephrons were equal in both the experimental and control rats. The fractional proximal resorption rate was notably greater in cirrhotic rats, as was the total proximal nephron resorption rate. That increased proximal resorption alone might account for diminished sodium and water excretion cannot be demonstrated from this study, although we believe that major evidence is provided of the importance of proximal resorption in this phenomenon.
本研究的目的是定位慢性肝硬化大鼠体内钠重吸收增加的部位。通过给予苯巴比妥和四氯化碳诱导肝硬化。动物在负荷后潴留盐和水，并出现水肿和腹水。进行了盐和水平衡、清除率及微穿刺试验。在开始诱导损伤的程序五或六周后，大鼠不能迅速排出盐和水负荷。有水肿和腹水的肝硬化大鼠的尿流量和钠浓度明显低于正常对照组。右侧未进行微穿刺的肾脏的肾小球滤过率略低，但左侧相同。实验大鼠和对照大鼠的表层肾单位的肾单位肾小球滤过率相等。肝硬化大鼠的近端重吸收率显著更高，近端肾单位总重吸收率也是如此。尽管我们认为本研究提供了近端重吸收在这一现象中的重要性的主要证据，但仅近端重吸收增加可能导致钠和水排泄减少这一点无法从本研究中得到证实。
