Gonçalves L, Providência L A
Serviço de Cardiologia, Hospitais da Universidade de Coimbra.
Rev Port Cardiol. 1993 Apr;12(4):361-73.
Myocardial reperfusion is today the best alternative to save ischemic myocardium. However, reperfusion carries with him an aggressive potential that may mask its benefits. From a clinical point of view, it is necessary to create new complementary therapies to prevent such injury. One of such therapy in which a great deal of knowledge in experimental models has been accumulated is superoxide dismutase. In this work are presented some chemical, biological, and pharmacological characteristics of this enzyme. Several forms of reperfusion injury are discussed as well as the role of superoxide dismutase in their prevention. The experience gathered along the years is still small for prevention of cellular oedema, intramyocardial haemorrhage, and low/no-reflow. There is still some controversy about the role of superoxide dismutase in the reduction of myocardial necrosis. However, superoxide dismutase seems to be highly protective, as far as stunned myocardium and reperfusion arrhythmias are concerned.
心肌再灌注是目前挽救缺血心肌的最佳选择。然而，再灌注本身具有一种潜在的不良作用，可能会掩盖其益处。从临床角度来看，有必要开发新的辅助疗法来预防这种损伤。超氧化物歧化酶就是在实验模型中积累了大量知识的此类疗法之一。本文介绍了该酶的一些化学、生物学和药理学特性。讨论了几种形式的再灌注损伤以及超氧化物歧化酶在预防这些损伤中的作用。多年来积累的经验在预防细胞水肿、心肌内出血和低灌注/无复流方面仍然有限。关于超氧化物歧化酶在减少心肌坏死中的作用仍存在一些争议。然而，就顿抑心肌和再灌注心律失常而言，超氧化物歧化酶似乎具有高度的保护作用。
