Kolowca J
Oddziału Wewnetrznego Szpitala ZOZ, Biskupcu.
Pol Tyg Lek. 1993;48(14-15):299-302.
Free oxygen radicals are highly active oxygen compounds contributing to several pathological states. A possible source of free oxygen radicals during reversible ischemic heart disease and mechanisms of their toxicity to the myocardium are discussed. Despite controversial results of clinical trials with the use of antioxidants in reducing an area of necrosis in the experimental myocardial infarction, it seems that free oxygen radicals play an important role in ischemic-reperfusion heart disease. Some promising results with the use of antioxidants (significant decrease in dyskinesis of ischemic left ventricular muscle and reduction of cardiac arrhythmias incidence) may be of clinical importance.
游离氧自由基是具有高度活性的含氧化合物，可导致多种病理状态。本文讨论了可逆性缺血性心脏病期间游离氧自由基的可能来源及其对心肌的毒性机制。尽管在实验性心肌梗死中使用抗氧化剂减少坏死面积的临床试验结果存在争议，但游离氧自由基似乎在缺血再灌注性心脏病中起重要作用。使用抗氧化剂取得的一些有前景的结果（缺血性左心室肌肉运动障碍显著减轻以及心律失常发生率降低）可能具有临床意义。
