Johansen C, Soll-Johanning H, Kolstad H, Lynge E, Carstensen B
Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen.
APMIS Suppl. 1993;33:35-76.
Cancers of the digestive organs and peritoneum constituted 28% of all cancers in Denmark in 1943-87. The lack of a common trend in incidence rates for the different tumour types indicates different aetiologies. Survival is worst for cancer of the oesophagus and improves gradually for cancer of the stomach, cancer of the small intestine and colorectal cancers. Survival from these tumours differ little between the sexes, but females have a slightly more favourable prognosis, which is most pronounced for sites with the best survival. The changes in survival over the study period, 1943-87, show virtually no change in the prognosis for oesophageal cancer, very slight, if any, improvement in that for stomach cancer, a detectable improvement in survival from cancer of the small intestine and substantial improvements in survival from colorectal cancer. Survival rates after colorectal cancer appear to be lower in Denmark than those seen in the USA. This finding may be due to the exclusion of certain precancerous lesions from the Danish material, which is not possible in US studies. Cancers of the liver, gallbladder and pancreas all carry extremely high mortality rates, with five-year survival rates below 5%, and one-year survival rates below 5% for cancers of the liver and pancreas.
1943年至1987年期间,丹麦消化系统器官和腹膜癌占所有癌症的28%。不同肿瘤类型发病率缺乏共同趋势表明病因不同。食管癌的生存率最差,而胃癌、小肠癌和结直肠癌的生存率则逐渐提高。这些肿瘤的生存率在性别之间差异不大,但女性的预后略好,在生存率最佳的部位最为明显。在1943年至1987年的研究期间,生存率的变化显示食管癌的预后几乎没有变化,胃癌的预后即使有改善也非常轻微,小肠癌的生存率有可检测到的改善,结直肠癌的生存率有显著改善。丹麦结直肠癌后的生存率似乎低于美国。这一发现可能是由于丹麦的材料排除了某些癌前病变,而美国的研究无法做到这一点。肝癌、胆囊癌和胰腺癌的死亡率都极高,五年生存率低于5%,肝癌和胰腺癌的一年生存率低于5%。