Caboche J, Vernier P, Rogard M, Besson M J
Laboratoire de Neurochimie-Anatomie, URA 1488, Université P et M. Curie, Paris, France.
Neuroreport. 1993 May;4(5):551-4. doi: 10.1097/00001756-199305000-00022.
Dopamine exerts a tonic inhibitory control in the regulation of mRNA encoding preproenkephalin (PPE), the precursor of enkephalin, in the dorsal part of the rat striatum. Less is known about the role of this amine in the regulation of PPE mRNA in the ventral part of the striatum which corresponds to the nucleus accumbens. In this study, the effects of an interruption of dopamine transmission by haloperidol (a dopaminergic receptor antagonist) were examined in the rat nucleus accumbens. The levels of PPE mRNA were analysed by in situ hybridization histochemistry by taking into account the complexity of the nucleus accumbens, i.e. by differentiating the rostro-caudal extension of the structure. It was found that PPE mRNA content was increased significantly only in the caudal part of the nucleus, indicating rostro-caudal differences in the haloperidol effects. The differential reactivity of PPE mRNA to dopaminergic receptor blockade and to a lesion of dopaminergic neurones along the rostrocaudal axis of the ventral striatum is discussed.
多巴胺在大鼠纹状体背侧对脑啡肽原（PPE，脑啡肽的前体）编码mRNA的调节中发挥着持续性抑制作用。关于这种胺在对应伏隔核的纹状体腹侧PPE mRNA调节中的作用，人们了解较少。在本研究中，研究了氟哌啶醇（一种多巴胺能受体拮抗剂）中断多巴胺传递对大鼠伏隔核的影响。通过原位杂交组织化学分析PPE mRNA水平，同时考虑到伏隔核的复杂性，即区分该结构的头-尾延伸。结果发现，仅在伏隔核的尾部PPE mRNA含量显著增加，表明氟哌啶醇的作用存在头-尾差异。本文讨论了PPE mRNA对多巴胺能受体阻断以及沿腹侧纹状体头-尾轴多巴胺能神经元损伤的不同反应性。
