Hamann G, Isenberg E, Stoll M, Huber G, Strittmatter M, Schimrigk K
Department of Neurology, University of the Saarland, Homburg/Saar, Germany.
Neuroreport. 1993 May;4(5):595-8. doi: 10.1097/00001756-199305000-00035.
Blood extent and localization visible in CCT predicts complications and prognosis in patients suffering from subarachnoid haemorrhage (SAH). Plasma renin activity (PRA) elevation is one of the hormonal parameters of autonomic disorders after SAH and its prognostic relevance could be confirmed by this study, too. But the correlation of PRA with blood amount and distribution was the main target of this study. Large amounts of blood are connected with higher PRA-levels and more PRA-rises. Even a linear correlation between the amount of blood defined by a CCT-score and PRA in ng ml h-2 could be established. A significant correlation was found between intraventricular, suprasellar blood, ventricular enlargement of the third/lateral ventricles and PRA-elevations. Disorders of hypothalamic and/or medullary centres of sympathetic control are thought to be the underlying cause and to depend on blood extent and distribution.
在计算机断层扫描（CCT）中可见的血液范围和定位可预测蛛网膜下腔出血（SAH）患者的并发症和预后。血浆肾素活性（PRA）升高是SAH后自主神经功能紊乱的激素参数之一，本研究也证实了其预后相关性。但本研究的主要目标是PRA与血量及分布的相关性。大量血液与较高的PRA水平及更多的PRA升高相关。甚至可以建立由CCT评分定义的血量与PRA（ng/ml/h²）之间的线性相关性。发现脑室内、鞍上血液、第三/侧脑室扩大与PRA升高之间存在显著相关性。下丘脑和/或延髓交感神经控制中心的紊乱被认为是潜在原因，且取决于血液范围和分布。
