Weeda G, Hoeijmakers J H
Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
Semin Cancer Biol. 1993 Apr;4(2):105-17.
Nucleotide excision repair is a versatile process and is one of the best known systems that prevents the deleterious consequences of DNA damage induced by environmental agents and cellular metabolites. Without repair, persisting lesions can interfere with proper functioning of DNA-metabolizing processes, notably transcription and replication, and give rise to mutations. The effect of inefficient or deficient repair is illustrated by genetic repair diseases that predispose individuals to cancer due to the fact that mutations accumulate at a high rate. Here we describe the progress that has been made from the initial cloning and characterization of nucleotide excision repair genes to the current understanding of their function in the complex nucleotide excision repair process.
核苷酸切除修复是一个多功能过程，是最知名的系统之一，可防止环境因素和细胞代谢产物诱导的DNA损伤产生有害后果。如果不进行修复，持续存在的损伤会干扰DNA代谢过程的正常功能，尤其是转录和复制，并导致突变。遗传修复疾病说明了修复效率低下或缺陷所产生的影响，这些疾病使个体易患癌症，因为突变以很高的速率积累。在这里，我们描述了从核苷酸切除修复基因的最初克隆和表征到目前对其在复杂的核苷酸切除修复过程中功能的理解所取得的进展。
