Weber G, Bianciardi G, Simoes C, Attino V, Tarabocchia B, Tanganelli P
Centro Ricerche Arteriosclerosi, Università di Siena, Italy.
Clin Exp Hypertens. 1993;15 Suppl 1:31-8.
As the Morphometric Reference Center of the WHO-ISFC PBDAY Project (Pathobiological Determinants of Atherosclerosis in Youth) we are studying lesion involvement of left hemiaortas of young people from different parts of the world. Gross specimens were stained and photographed at the Malmö reference Center (Dir. Prof. N.H. Sternby). Percentage of lipid lesions were evaluated and probability maps of lipid lesion distribution at the aortic surface were obtained by image processing. In all samples from Italy, Mexico and Sri Lanka, high probability of lipid lesion occurrence was found between the emergences of the intercostal arteries, next to the emergence of the celiac trunk, between the emergence of the superior and inferior lumbar arteries and between the emergence of the 1st and the 2nd mesenteric arteries. Our data reveal that a) lipid lesions are localized in low shear-stress regions or in turbuecent regions; b) our samples taken from groups of different geographical origin present the same lipid lesion distribution at the aortic surface.
作为世界卫生组织-国际心脏病理学会青少年动脉粥样硬化病理生物学决定因素（PBDAY）项目的形态测量参考中心，我们正在研究来自世界不同地区年轻人左半主动脉的病变情况。大体标本在马尔默参考中心（主任：N.H. 斯特恩比教授）进行染色和拍照。通过图像处理评估脂质病变的百分比，并获得主动脉表面脂质病变分布的概率图。在来自意大利、墨西哥和斯里兰卡的所有样本中，发现脂质病变出现的高概率区域位于肋间动脉发出处之间、腹腔干发出处旁边、上、下腰动脉发出处之间以及第一和第二肠系膜动脉发出处之间。我们的数据表明：a）脂质病变位于低剪切应力区域或湍流区域；b）我们从不同地理来源组采集的样本在主动脉表面呈现相同的脂质病变分布。
