Cornhill J F, Herderick E E, Stary H C
Department of Surgery, Ohio State University, Columbus.
Monogr Atheroscler. 1990;15:13-9.
The topographic distribution of sudanophilic lesions in the human aorta has been defined using probability-of-occurrence maps for a population dying of trauma (male, black and white, 15-29 years, n = 109). The maps demonstrate that sudanophilic lesions are localized with a characteristic topography. Regions of high probability (greater than 60%) occurred in close proximity to regions of low probability (less than 10%). Although some high-probability areas are associated with expected low wall shear stress regions, many other high probability areas are not and thus no specific causal hemodynamic localizing factors could be identified. The probability maps do however form an important basis for the development of rational strategies of tissue sampling in studies concerned with the characterization of localizing factors (biochemical, cellular, hemodynamic, and structural) and their relationship to putative atherogenic mechanisms.
利用针对因创伤死亡人群（男性，黑人和白人，15 - 29岁，n = 109）的发生概率图，已明确了人类主动脉中嗜苏丹性病变的地形分布。这些图表明嗜苏丹性病变具有特征性的地形定位。高概率区域（大于60%）紧邻低概率区域（小于10%）。尽管一些高概率区域与预期的低壁面剪应力区域相关，但许多其他高概率区域并非如此，因此无法确定特定的因果血流动力学定位因素。然而，这些概率图确实为在有关定位因素（生化、细胞、血流动力学和结构）及其与假定动脉粥样硬化机制关系的研究中制定合理的组织采样策略奠定了重要基础。
