Grcevska L, Polenaković M, Ferluga D, Vizjak A, Stavrić G
Department of Nephrology, Faculty of Medicine, Skopje, Macedonia.
Clin Nephrol. 1993 May;39(5):250-3.
We report on a patient who suffered from psoriasis vulgaris and psoriatic arthritis and developed nephrotic syndrome after long-term therapy with non-steroidal anti-inflammatory drugs. Membranous nephropathy with tubulointerstitial and vascular (intimal hyperplasia) changes were found on renal biopsy using optical, immunofluorescent and electron microscopy. Treatment with methylprednisolone "pulse" therapy (1 g/24 h during 3 days) and continuing with prednisone 0.5 mg/kg/24 h was ineffective and end-stage renal failure developed 6 months after the diagnosis had been established.
我们报告了一名患有寻常型银屑病和银屑病关节炎的患者，在长期使用非甾体抗炎药治疗后出现了肾病综合征。通过光学显微镜、免疫荧光显微镜和电子显微镜进行肾活检，发现为膜性肾病伴有肾小管间质和血管（内膜增生）改变。采用甲泼尼龙“冲击”疗法（3天内每天1克）并继续使用泼尼松0.5毫克/千克/天进行治疗无效，在确诊后6个月发展为终末期肾衰竭。
