Atanasova P, Dimitrova D, Milkov V
Vutr Boles. 1989;28(6):79-82.
A case of a man suffering from psoriasis vulgaris is presented. The onset of the disease was at the age of 5. From the age of 14 all joints were gradually affected by the type of severe, symmetrical psoriatic arthritis which led to aseptic necrosis of the hip joints. In the course of the disease, from 1988 on, proteinuria and nephrotic syndrome were found. The renal biopsy proved amyloidosis which is considered secondary, developed on the basis of psoriatic arthritis. The severe psoriatic arthritis with especially emphasized clinical activity is in this case the pathologic antigenic stimulus for the amyloid formation. The clinical course and the histologic findings from the renal biopsy point to serious structural disorders of the renal parenchyma which determine the progressing tendency toward chronic renal failure.
本文介绍了一例寻常型银屑病患者。该疾病于5岁时发病。从14岁起，所有关节逐渐受到严重的对称性银屑病关节炎影响，导致髋关节无菌性坏死。在疾病过程中，自1988年起，发现蛋白尿和肾病综合征。肾活检证实为淀粉样变性，认为是继发性的，在银屑病关节炎的基础上发展而来。在这种情况下，严重的银屑病关节炎，尤其是突出的临床活动，是淀粉样蛋白形成的病理抗原刺激因素。肾活检的临床过程和组织学结果表明肾实质存在严重的结构紊乱，这决定了向慢性肾衰竭发展的趋势。
