Hurkadli K S, Vernekar V J, Sheth A R
Institute for Research in Reproduction (ICMR), Parel Bombay, India.
Contraception. 1993 May;47(5):491-8. doi: 10.1016/0010-7824(93)90101-c.
Adult female rats were actively immunized with sperm-coating protein (10.4 KDa) human seminal plasma inhibin (HSPI). Following 8 weeks of immunization at 2.5 micrograms and 5 micrograms doses of HSPI with Freund's complete adjuvant, antifertility effects were observed in 63% (5/8) and 88% (7/8) of animals, respectively. Estrous cycle was not affected in experimental group. Thus, the present study suggests the potential use of HSPI for immunocontraception in females.
成年雌性大鼠用精子包被蛋白（10.4千道尔顿）人精浆抑制素（HSPI）进行主动免疫。在用弗氏完全佐剂以2.5微克和5微克剂量的HSPI免疫8周后，分别在63%（5/8）和88%（7/8）的动物中观察到抗生育作用。实验组的发情周期未受影响。因此，本研究表明HSPI在女性免疫避孕方面具有潜在用途。
