Abei M, Tanaka N, Matsumoto H, Chiba T, Matsuzaki Y, Nishi M, Chuganji Y, Fukutomi H, Osuga T
Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Gastrointest Endosc. 1993 May-Jun;39(3):406-9. doi: 10.1016/s0016-5107(93)70116-9.
We investigated the significance of intravenous injection of indocyanine green during laparoscopic examination in chronic hepatitis. The presence or absence of bridging fibrosis was estimated during laparoscopy from the pattern of lobular markings before and after indocyanine green coloration. Laparoscopy without indocyanine green predicted the presence of bridging fibrosis in biopsy specimens with a low sensitivity of 0.42 (specificity, 0.8). After intravenous injection of indocyanine green, lobular markings became clearer and the sensitivity of laparoscopy in the diagnosis of bridging fibrosis was markedly increased (sensitivity, 0.89; specificity, 0.8). These results indicate that the indocyanine green coloration method improves the correspondence between laparoscopy and liver biopsy in evaluating the severity of chronic hepatitis.
我们研究了在慢性肝炎腹腔镜检查期间静脉注射吲哚菁绿的意义。在腹腔镜检查过程中，根据吲哚菁绿染色前后小叶标记的模式来评估桥接纤维化的有无。未使用吲哚菁绿的腹腔镜检查预测活检标本中桥接纤维化存在的敏感性较低，为0.42（特异性为0.8）。静脉注射吲哚菁绿后，小叶标记变得更清晰，腹腔镜检查诊断桥接纤维化的敏感性显著提高（敏感性为0.89；特异性为0.8）。这些结果表明，吲哚菁绿染色法在评估慢性肝炎严重程度时可改善腹腔镜检查与肝活检之间的一致性。
