Crawford D H, Halliday J W, Cooksley W G, Murphy T L, Golding S D, Wallace J D, Cuneo R C, Lynch S V, Strong R J, Powell L W
Joint Liver Program, University of Queensland, Royal Brisbane Hospital, Australia.
Hepatology. 1993 Jun;17(6):1016-21.
We compared total body water and intracellular-extracellular distribution of body water between male patients with mild liver disease without ascites (n = 9), male patients with severe liver disease and gross ascites (n = 6) and a group of age-, sex-, height- and weight- matched controls (n = 6). In addition, we documented the effects of liver transplantation on intracellular, extracellular and total body water in 12 patients (6 men and 6 women) by means of deuterium oxide dilution and whole-body potassium counting. We saw no significant difference in total body water between the healthy controls, patients without ascites and patients with ascites (46.5 +/- 9.2 kg, 45.4 +/- 6.6 kg and 50.4 +/- 5.1 kg, respectively), although, as expected, extracellular water was increased in patients with ascites compared with healthy controls and cirrhotic patients without ascites (36.9 +/- 6.5 kg vs. 25.4 +/- 4.4 kg, p = 0.005; and 36.9 +/- 6.5 kg vs. 27.0 +/- 5.3 kg, p = 0.002, respectively). We found no difference between non-ascitic patients and healthy controls (25.4 +/- 4.4 kg vs. 27.0 +/- 5.3 kg). However, intracellular water was significantly reduced in patients with severe liver disease compared with that in controls (13.6 +/- 3.3 kg vs. 21.5 +/- 4.2 kg, p = 0.005) or patients without ascites (13.6 +/- 3.3 kg vs. 18.3 +/- 2.9 kg, p = 0.01). The reduction of intracellular water appears to be due to loss of body cell mass.(ABSTRACT TRUNCATED AT 250 WORDS)
我们比较了无腹水的轻度肝病男性患者（n = 9）、有严重肝病和大量腹水的男性患者（n = 6）以及一组年龄、性别、身高和体重匹配的对照组（n = 6）之间的总体水含量以及体内水的细胞内-细胞外分布情况。此外，我们通过氧化氘稀释法和全身钾计数记录了12例患者（6名男性和6名女性）肝移植对细胞内、细胞外和总体水含量的影响。我们发现健康对照组、无腹水患者和有腹水患者之间的总体水含量无显著差异（分别为46.5±9.2 kg、45.4±6.6 kg和50.4±5.1 kg），不过，正如预期的那样，与健康对照组和无腹水的肝硬化患者相比，有腹水患者的细胞外水增加（分别为36.9±6.5 kg对25.4±4.4 kg，p = 0.005；以及36.9±6.5 kg对27.0±5.3 kg，p = 0.002）。我们发现无腹水患者和健康对照组之间无差异（25.4±4.4 kg对27.0±5.3 kg）。然而，与对照组（13.6±3.3 kg对21.5±4.2 kg，p = 0.005）或无腹水患者（13.6±3.3 kg对18.3±2.9 kg，p = 0.01）相比，严重肝病患者的细胞内水显著减少。细胞内水的减少似乎是由于体细胞质量的丧失。（摘要截断于250字）
