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婴儿期苯巴比妥中毒的血液透析治疗

Haemodialysis treatment in phenobarbital intoxication in infancy.

作者信息

Söylemezoğlu O, Bakkaloğlu A, Yiğit S, Saatçi U

机构信息

Faculty of Medicine, Hacettepe University, Ankara, Turkey.

出版信息

Int Urol Nephrol. 1993;25(1):111-3. doi: 10.1007/BF02552263.

DOI:10.1007/BF02552263
PMID:8514469
Abstract

Haemodialysis treatment was performed in a comatose infant who was 9 months old. At the beginning of haemodialysis plasma phenobarbital concentration was found to be 120 micrograms/ml. The constant low flux haemodialysis lowered the plasma phenobarbital concentration to 64.2 micrograms/ml and haemodialysis was terminated at the end of six hours. The patient recovered fully after haemodialysis session. This case indicates that haemodialysis is an effective and successful treatment method in phenobarbital intoxication also in infancy.

摘要

对一名9个月大的昏迷婴儿进行了血液透析治疗。血液透析开始时,血浆苯巴比妥浓度为120微克/毫升。持续的低通量血液透析将血浆苯巴比妥浓度降至64.2微克/毫升,6小时结束时终止血液透析。血液透析疗程结束后,患者完全康复。该病例表明,血液透析也是婴儿期苯巴比妥中毒的一种有效且成功的治疗方法。

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Haemodialysis treatment in phenobarbital intoxication in infancy.婴儿期苯巴比妥中毒的血液透析治疗
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引用本文的文献

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Population Pharmacokinetics of Phenobarbital in Neonates and Infants on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy.体外膜肺氧合新生儿和婴儿苯巴比妥的群体药代动力学及肾替代治疗的影响。
J Clin Pharmacol. 2021 Mar;61(3):378-387. doi: 10.1002/jcph.1743. Epub 2020 Sep 22.
2
Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.儿童中毒处理中的肾脏替代治疗:儿科持续肾脏替代治疗(PCRRT)工作组的建议。
Pediatr Nephrol. 2019 Nov;34(11):2427-2448. doi: 10.1007/s00467-019-04319-2. Epub 2019 Aug 24.

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Assessment of barbiturate removal by charcoal hemoperfusion in overdose cases.过量用药病例中通过活性炭血液灌流评估巴比妥类药物清除情况。
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