Jacobsen D, Wiik-Larsen E, Dahl T, Enger E, Lunde P K
Eur J Clin Pharmacol. 1984;26(1):109-12. doi: 10.1007/BF00546717.
Charcoal haemoperfusion was performed for 5-12 h in three patients with maximal plasma phenobarbital concentrations of 600, 946 and 1044 mumol/l (138, 217 and 240 micrograms/ml). During haemoperfusion with constant blood flow phenobarbital elimination followed first order kinetics with half-lives of 11.1, 10.0 and 7.2 h, respectively. After termination of the haemoperfusion there was no rebound effect in plasma phenobarbital concentration and the elimination was first order with half-lives of 51, 82 and 48 h, respectively. Thus, the plasma phenobarbital half-life was reduced by 78-88% during haemoperfusion. In the same period 76-86% of the total body clearance of phenobarbital was due to the haemoperfusion column at a calculated volume of distribution of phenobarbital of 1.1-1.21/kg. This is clear evidence for recommending haemoperfusion in cases of serious poisoning with phenobarbital.
对3例最大血浆苯巴比妥浓度分别为600、946和1044μmol/L（138、217和240μg/ml）的患者进行了5 - 12小时的血液灌流。在恒速血流血液灌流过程中，苯巴比妥的消除遵循一级动力学，半衰期分别为11.1、10.0和7.2小时。血液灌流结束后，血浆苯巴比妥浓度无反跳效应，消除为一级动力学，半衰期分别为51、82和48小时。因此，血液灌流期间血浆苯巴比妥半衰期缩短了78 - 88%。在同一时期，苯巴比妥总体清除率的76 - 86%归因于血液灌流柱，计算得出的苯巴比妥分布容积为1.1 - 1.21/kg。这是在苯巴比妥严重中毒病例中推荐血液灌流的明确证据。
