Gandar R, Collin D
Département de Gynécologie-Obstétrique, Centre Hospitalier Général, Haguenau.
J Gynecol Obstet Biol Reprod (Paris). 1993;22(2):127-32.
Functional hypothalamic amenorrhea are very probably due to a decrease of the frequency of the secretory pulses of LH, ie of GnRH. This decrease could be the consequence of a chronic hypersecretion of the corticotropin releasing hormone (CRH). CRH seems to act on the hypotalamic pulse generator of GnRH through the effect of the endogenous opioid peptides of the central nervous system. Opioid receptor antagonists restore normal pulse frequency of LH in most cases. Research is being done to try to elucidate the cause of the failure to such treatment: dopamine in among other mechanisms, supposed to play an essential role.
功能性下丘脑性闭经很可能是由于促黄体生成素（LH）分泌脉冲频率降低，即促性腺激素释放激素（GnRH）分泌脉冲频率降低所致。这种降低可能是促肾上腺皮质激素释放激素（CRH）慢性分泌过多的结果。CRH似乎通过中枢神经系统内源性阿片肽的作用，作用于GnRH的下丘脑脉冲发生器。在大多数情况下，阿片受体拮抗剂可恢复LH的正常脉冲频率。目前正在进行研究，试图阐明这种治疗失败的原因：多巴胺在多种机制中被认为起着重要作用。
