Scarlatti G, Albert J, Rossi P, Hodara V, Biraghi P, Muggiasca L, Fenyö E M
Department of Virology, Karolinska Institute, Stockholm, Sweden.
J Infect Dis. 1993 Jul;168(1):207-10. doi: 10.1093/infdis/168.1.207.
The aim of this study was to investigate the influence of neutralizing antibodies in mother's serum on the risk of mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). Sera from 20 HIV-1 infected mothers were analyzed for their ability to neutralize their own virus (autologous neutralization) and virus obtained from other mothers (heterologous neutralization). A statistically significant correlation was found between the capacity to neutralize 1 selected primary isolate and protection of the child from infection. Also, neutralizing antibodies against autologous virus were more frequently present in nontransmitting mothers than in transmitting mothers (5 and 2, respectively, of 10 mothers). The mothers with autologous neutralizing antibodies also neutralized at least 2 heterologous primary isolates. Thus, mothers with neutralizing antibodies to primary HIV-1 isolates have a reduced risk of infecting their children.
本研究的目的是调查母亲血清中的中和抗体对1型人类免疫缺陷病毒（HIV-1）母婴传播风险的影响。分析了20名感染HIV-1的母亲的血清中和自身病毒（自体中和）以及中和从其他母亲处获得的病毒（异体中和）的能力。在中和1株选定的原始病毒株的能力与保护儿童免受感染之间发现了具有统计学意义的相关性。此外，未发生传播的母亲中比发生传播的母亲更频繁地出现针对自体病毒的中和抗体（10名母亲中分别为5名和2名）。具有自体中和抗体的母亲也至少中和了2株异体原始病毒株。因此，对HIV-1原始病毒株具有中和抗体的母亲感染其子女的风险降低。
