Suzuki Y, Suzuki T
Department of Internal Medicine, Ohme City General Hospital, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Feb;31(2):146-53.
We have recently observed six patients with acute interstitial eosinophilic pneumonia. All the patients suffered from an acute febrile illness and severe hypoxemia. Their chest films showed diffuse interstitial infiltrates. Kerley's A and B lines and pleural effusions are characteristic and important for the diagnosis of acute interstitial eosinophilic pneumonia, as they are frequently observed. Eosinophilia in peripheral blood was not initially present in any of the patients. Mild to severe eosinophilia was present during their convalescence. Histological examination showed eosinophilic infiltration of the alveolar walls and spaces. Half of the patients improved following treatment with corticosteroids, and the rest of the patients improved without treatment. To make an early diagnosis, this type of eosinophilic pneumonia should always be considered. It is important to recognize the radiographic findings, that is Kerley's lines and pleural changes, noted in this study. It should be noted that the number of eosinophils in peripheral blood has a tendency to be low during the acute phase.
我们最近观察了6例急性间质性嗜酸性粒细胞性肺炎患者。所有患者均患有急性发热性疾病和严重低氧血症。他们的胸部X光片显示弥漫性间质性浸润。克氏A线和B线以及胸腔积液具有特征性且对急性间质性嗜酸性粒细胞性肺炎的诊断很重要，因为它们经常被观察到。所有患者最初外周血中均未出现嗜酸性粒细胞增多。在恢复期出现轻度至重度嗜酸性粒细胞增多。组织学检查显示肺泡壁和肺泡腔有嗜酸性粒细胞浸润。一半的患者经皮质类固醇治疗后病情好转，其余患者未经治疗也有所好转。为了早期诊断，应始终考虑这种类型的嗜酸性粒细胞性肺炎。认识到本研究中提到的影像学表现，即克氏线和胸膜改变，很重要。应当注意，急性期外周血中嗜酸性粒细胞数量往往较低。
