Nomori H, Kobayashi R, Takahashi Y, Iga R, Morinaga S
Department of Surgery, Saiseikai Central Hospital.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Feb;31(2):261-6.
A 57-year-old male presented with palpitations and dyspnea on exertion. Examination of the peripheral blood and bone marrow showed pancytopenia with marked red cell aplasia. Hypogammaglobulinemia was also recognized. Chest X-ray and CT showed a mass in the anterior mediastinum. A biopsy showed thymoma. Two months after admission, the patient died of sepsis secondary to worsening pancytopenia and hypogammaglobulinemia. Autopsy showed non-invasive spindle cell type thymoma and a marked decrease of hematogenous cells. Review of the literature indicates that pancytopenia associated with thymoma is resistant to all forms of treatment and its prognosis is poor.
一名57岁男性因心悸和劳力性呼吸困难就诊。外周血和骨髓检查显示全血细胞减少伴明显的红细胞再生障碍。还发现有低丙种球蛋白血症。胸部X线和CT显示前纵隔有一肿块。活检显示为胸腺瘤。入院两个月后，患者因全血细胞减少和低丙种球蛋白血症恶化继发败血症死亡。尸检显示为非侵袭性梭形细胞型胸腺瘤，造血细胞明显减少。文献回顾表明，与胸腺瘤相关的全血细胞减少对所有治疗形式均耐药，预后不良。
