Grignaschi G, Mantelli B, Samanin R
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Neurosci Lett. 1993 Apr 2;152(1-2):103-6. doi: 10.1016/0304-3940(93)90494-6.
Ritanserin (0.5 and 1 mg/kg) and ketanserin (2.5 mg/kg), two antagonists with high affinity for 5-HT2 receptors, attenuated restraint stress-induced hypophagia in rats. Two injections of the 5-HT2 receptor antagonist cinanserin (30 nmol/0.5 microliter) in the paraventricular nucleus of the hypothalamus completely reversed the effect of stress on food intake. (+/-)Cyanopindolol (3 and 8 mg/kg), an antagonist at 5-HT1A and 5-HT1B receptors, had no effect whereas 8-hydroxy-2-di-n-propylamino)tetralin (30-300 micrograms/kg), an agonist at 5-HT1A receptors, significantly attenuated the hypophagia. The results suggest that restraint stress-induced hypophagia is mediated by 5-HT2 receptors in the paraventricular nucleus of the hypothalamus. The potential utility of this model in anorexia nervosa is discussed.
利坦色林（0.5和1毫克/千克）和酮色林（2.5毫克/千克）这两种对5-羟色胺2（5-HT2）受体具有高亲和力的拮抗剂，可减轻大鼠束缚应激诱导的摄食减少。在下丘脑室旁核注射两次5-HT2受体拮抗剂西那色林（30纳摩尔/0.5微升）可完全逆转应激对食物摄入的影响。5-HT1A和5-HT1B受体拮抗剂（±）氰吲哚洛尔（3和8毫克/千克）没有效果，而5-HT1A受体激动剂8-羟基-2-二正丙基氨基四氢萘（30-300微克/千克）可显著减轻摄食减少。结果表明，束缚应激诱导的摄食减少是由下丘脑室旁核中的5-HT2受体介导的。本文讨论了该模型在神经性厌食症中的潜在应用。
