Tinkelman D G, Reed C E, Nelson H S, Offord K P
American Academy of Allergy and Immunology Beclomethasone Dipropionate-Theophylline Study Group, Milwaukee, WI.
Pediatrics. 1993 Jul;92(1):64-77.
To compare the benefits and adverse reactions of theophylline and beclomethasone (BDP) in the long-term control of mild to moderate chronic asthma in children.
Multicentered, double-blind, double-placebo, randomized, controlled trial.
One hundred ninety-five children between the ages of 6 and 16 years with mild to moderate asthma.
Treatment with either BDP, 84 micrograms four times a day, or sustained-release theophylline administered twice daily in doses adjusted for optimum control of symptoms.
Daily diary record of symptoms, peak flow rates, supplemental bronchodilator and glucocorticoid treatment, doctor and hospital visits, absence from work and school, and side effects.
Aerosol BDP and sustained-release theophylline were effective primary treatments for mild to moderate chronic asthma. Beclomethasone resulted in comparable symptom control with less bronchodilator use and fewer courses of systemic steroids than did theophylline. Side effects were observed significantly more frequently with theophylline than with BDP. Growth velocity suppression was noted with BDP and was more pronounced in boys. Suppression was not associated with alterations in cortisol measurements either at baseline or following stimulation.
Both theophylline and BDP are effective therapy for mild to moderate asthma. Caution must be used with the administration of BDP in children because of possible growth velocity suppression.
比较茶碱和倍氯米松（BDP）在长期控制儿童轻至中度慢性哮喘中的疗效和不良反应。
多中心、双盲、双安慰剂、随机对照试验。
195名年龄在6至16岁之间的轻至中度哮喘儿童。
使用BDP，每日4次，每次84微克，或使用缓释茶碱，每日2次，剂量根据症状的最佳控制情况进行调整。
症状的每日日记记录、峰值流速、补充支气管扩张剂和糖皮质激素治疗、医生和医院就诊次数、缺勤和缺课情况以及副作用。
气雾剂BDP和缓释茶碱是治疗轻至中度慢性哮喘的有效主要药物。与茶碱相比，倍氯米松在控制症状方面效果相当，但使用支气管扩张剂较少，全身用类固醇疗程也较少。茶碱的副作用明显比BDP更常见。BDP可导致生长速度抑制，在男孩中更为明显。这种抑制与基线时或刺激后皮质醇测量值的改变无关。
茶碱和BDP都是治疗轻至中度哮喘的有效药物。由于可能抑制生长速度，儿童使用BDP时必须谨慎。
