艾滋病脊髓病。一项神经病理学研究。
AIDS-myelopathy. A neuropathological study.
作者信息
Bergmann M, Gullotta F, Kuchelmeister K, Masini T, Angeli G
机构信息
Department of Neuropathology University of Muenster, FRG.
出版信息
Pathol Res Pract. 1993 Feb;189(1):58-65. doi: 10.1016/S0344-0338(11)80117-2.
Abstract
Vacuolar myelopathy belongs to the AIDS-associated diseases. It is characterized by vacuolation and infiltration of the long tracts of the spinal cord by macrophages. The clinical and morphological findings of 8 AIDS-patients with vacuolar myelopathy are reported here. The syndrome developed during the final stages of AIDS and was associated with HIV-encephalopathy in 5 cases. The vacuoles were mainly due to intramyelinic swelling and vacuolation. Vacuolated macrophages and axons contributed only to a minor degree. In one case only, HIV-antigens were detected immunohistochemically. The results are discussed in the light of modern pathogenetical concepts of HIV-related diseases.
摘要
空泡性脊髓病属于艾滋病相关疾病。其特征为脊髓长束出现空泡形成以及巨噬细胞浸润。本文报告了8例患有空泡性脊髓病的艾滋病患者的临床和形态学表现。该综合征在艾滋病末期出现，5例患者伴有HIV脑病。空泡主要是由于髓鞘内肿胀和空泡形成。空泡化的巨噬细胞和轴突仅占较小比例。仅在1例患者中通过免疫组织化学检测到HIV抗原。根据HIV相关疾病的现代发病机制概念对结果进行了讨论。
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