Jay V, Edwards V, Squire J, Rutka J
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Pediatr Pathol. 1993 May-Jun;13(3):323-32. doi: 10.3109/15513819309048220.
Astroblastomas are rare tumors of cerebral hemispheres of young adults. We report an astroblastoma in a 15-year-old girl and present the first descriptions of cytogenetic abnormalities in this tumor. The tumor was relatively well demarcated from the brain and revealed prominent perivascular rosettes as well as intervascular clear cells that contained abundant glycogen. Cytogenetic analysis revealed an abnormal hypodiploid karyotype with 45 chromosomes and monosomies of chromosomes 10, 21, and 22 and two marker chromosomes in all cells examined. The tumor had a Ki-67 labelling index of 4.7% and assessment of ploidy by flow cytometry revealed 96% of cells in the G0G1 phase and 4% of cells in the G2M phase. Assessment of proliferation and ploidy indices in further cases may provide important prognostic data for this poorly understood entity. Further cytogenetic studies will also help to identify if there are consistent karyotypic abnormalities in these enigmatic tumors.
成星形细胞瘤是发生于年轻成年人脑半球的罕见肿瘤。我们报告了一例15岁女孩的成星形细胞瘤，并首次描述了该肿瘤的细胞遗传学异常。肿瘤与脑分界相对清晰，可见显著的血管周围菊形团以及血管间透明细胞，这些细胞含有丰富的糖原。细胞遗传学分析显示，在所有检测细胞中均存在异常的亚二倍体核型，有45条染色体，10号、21号和22号染色体单体以及两条标记染色体。该肿瘤的Ki-67标记指数为4.7%，通过流式细胞术评估倍性显示，96%的细胞处于G0G1期，4%的细胞处于G2M期。对更多病例的增殖和倍性指数评估可能为这个了解甚少的实体提供重要的预后数据。进一步的细胞遗传学研究也将有助于确定这些神秘肿瘤是否存在一致的核型异常。
