Novoderzhkina I S, Trubina I E, Boliakina G K, Volkov A V
Biull Eksp Biol Med. 1977 Mar;83(3):266-8.
A syndrome of low cardiac output developed between the 1st and the 3rd hours after the resuscitation in 16 dogs after the arrest of blood circulation for 15 minutes. The increase of cardiac output at the initial period of resuscitation took place in 50% of cases before the development of this syndrome. In the absence of hyperperfusion at the beginning of the resuscitation the animals died 9 to 23 hours after the experiment. Cerebral cortex edema developed in all the survived dogs which had low cardiac output 24 hours after resuscitation, but it was not observed in animals with high cardiac output.
16只狗在血液循环停止15分钟后进行复苏,在复苏后的第1至3小时出现了心输出量降低综合征。在该综合征出现之前,50%的病例在复苏初期心输出量增加。如果复苏开始时没有高灌注,动物在实验后9至23小时死亡。所有存活的狗在复苏24小时后若心输出量低,都会出现大脑皮质水肿,但心输出量高的动物未观察到这种情况。