Krengli M, Pastore G, Invernizzi A, Pisani P, Negri G
Radiol Med. 1993 Apr;85(4):472-5.
In the present study 90 patients affected with pyriform sinus carcinomas are analyzed. They underwent irradiation alone from 1970 to 1986. All cases were staged according to TNM criteria (UICC 1982): 7 were T1, 16 T2, 40 T3, 27 T4, 36 N0, 18 N1, 3 N2, 33 N3. Radiotherapy was performed with 60Co. In all cases doses of 60-70 Gy were delivered to T and N1 and doses of 45-50 Gy to N0. Locoregional control obtained in 35 patients (38.9%): 6/7 T1 (85.7%), 9/16 T2 (56.2%), 15/40 T3 (37.5%), 5/27 T4 (18.5%) and 20/36 N0, 8/18 N1, 1/3 N2, 6/33 N3. The overall and NED 3-year survival rates are 23.3% (21/90) and 20.0% (18/90), respectively; at 5 and 10 years all patients alive are NED, with survival rates of 12.2% (11/90) and 9.8% (5/51) respectively. Locoregional failures were observed in 12/35 cases (34.3%); 91% of them occurred within the first two years of follow up (mean: 10 months). Distant metastases appeared in 26/90 patients (28.9%) and secondary tumors occurred in 10/90 cases (11.1%). Our experience confirms radiotherapy to be an effective alternative treatment to surgery in the early stages (I-II) of pyriform sinus carcinomas, but no more than only a palliative treatment in stage III-IV cancers.
在本研究中，对90例梨状窦癌患者进行了分析。他们在1970年至1986年期间仅接受了放疗。所有病例均根据TNM标准（UICC 1982）进行分期：T1期7例，T2期16例，T3期40例，T4期27例，N0期36例，N1期18例，N2期3例，N3期33例。采用60钴进行放射治疗。所有病例中，T和N1区域给予60 - 70 Gy的剂量，N0区域给予45 - 50 Gy的剂量。35例患者（38.9%）获得了局部区域控制：T1期6/7例（85.7%），T2期9/16例（56.2%），T3期15/40例（37.5%），T4期5/27例（18.5%）以及N0期20/36例，N1期8/18例，N2期1/3例，N3期6/33例。总体3年生存率和无疾病证据（NED）生存率分别为23.3%（21/90）和20.0%（18/90）；在5年和10年时，所有存活患者均为NED，生存率分别为12.2%（11/90）和9.8%（5/51）。在35例病例中有12例（34.3%）观察到局部区域失败；其中91%发生在随访的前两年内（平均：10个月）。26/90例患者（28.9%）出现远处转移，10/90例病例（11.1%）发生第二原发肿瘤。我们的经验证实，放射治疗在梨状窦癌的早期阶段（I - II期）是一种有效的替代手术的治疗方法，但在III - IV期癌症中仅为姑息性治疗。
