Paksoy N, Hekim E
Department of Pathology, School of Medicine, University of Akdeniz Mediterranean, Antalya, Turkey.
Trop Med Parasitol. 1993 Mar;44(1):37-9.
Cutaneous leishmaniasis (LC) and lupus vulgaris (LV) are commonly encountered in the Mediterranean region of Turkey. Differential diagnosis is rather difficult and unreliable purely on clinical grounds; thus histopathological examination is required. Microscopical findings of both lesions may also present some similarities. 12 LC and 16 LV cases were analysed comparatively regarding the clinicopathological features. In the early stage of LC, macrophage granulomas containing numerous leishmania parasites was the key microscopic finding. In the late stage of LC, granulomas consisted of epithelioid histiocytes with scanty organisms were present. LV biopsies showed tuberculoid granulomas with Langhans type giant cells in all cases, and acid fast bacilli were detected only in two cases.
皮肤利什曼病（LC）和寻常狼疮（LV）在土耳其地中海地区较为常见。仅基于临床依据进行鉴别诊断相当困难且不可靠；因此需要进行组织病理学检查。两种病变的显微镜检查结果也可能存在一些相似之处。对12例LC和16例LV病例的临床病理特征进行了比较分析。在LC的早期，含有大量利什曼原虫寄生虫的巨噬细胞肉芽肿是关键的显微镜检查发现。在LC的晚期，肉芽肿由上皮样组织细胞组成，病原体较少。LV活检在所有病例中均显示有朗汉斯型巨细胞的结核样肉芽肿，仅在两例中检测到抗酸杆菌。
