Ness D K, Schantz S L, Moshtaghian J, Hansen L G
Department of Veterinary Biosciences, University of Illinois, Urbana 61801.
Toxicol Lett. 1993 Jun;68(3):311-23. doi: 10.1016/0378-4274(93)90023-q.
Time-mated Sprague-Dawley rats were exposed to PCB 28 (2,4,4'-trichlorobiphenyl), 8 or 32 mg/kg/day; PCB 118 (2,3',4,4',5-pentachlorobiphenyl), 4 or 16 mg/kg/day; or PCB 153 (2,2',4,4',5,5'-hexachlorobiphenyl), 16 or 64 mg/kg/day. At weaning, serum thyroxine (T4) was markedly depressed in pups, but not dams, exposed to PCB 118 or 153. Triiodothyronine (T3) was unchanged in pups and dams. In a histological evaluation of thyroids, the PCB 118 pups revealed changes suggestive of sustained TSH stimulation, including increased follicular cell vacuolization and height, increased nuclear vesiculation, and decreased colloid area. Decreases in body and brain weights and increases in liver weights were observed in some groups, with the high dose PCB 118 pups showing the greatest effect.
将定时交配的斯普拉格-道利大鼠暴露于多氯联苯28（2,4,4'-三氯联苯），剂量为8或32毫克/千克/天；多氯联苯118（2,3',4,4',5-五氯联苯），剂量为4或16毫克/千克/天；或多氯联苯153（2,2',4,4',5,5'-六氯联苯），剂量为16或64毫克/千克/天。在断奶时，暴露于多氯联苯118或153的幼崽血清甲状腺素（T4）显著降低，但母鼠未出现这种情况。幼崽和母鼠的三碘甲状腺原氨酸（T3）没有变化。在甲状腺的组织学评估中，多氯联苯118组的幼崽显示出持续促甲状腺激素刺激的迹象，包括滤泡细胞空泡化和高度增加、核空泡化增加以及胶体面积减少。在一些组中观察到体重和脑重下降以及肝脏重量增加，高剂量多氯联苯118组的幼崽受影响最大。
