Jager M J, Kok F G, Broersma L, van der Gaaq R
Department of Ophthalmology, Leiden University Hospital, The Netherlands.
Transplantation. 1993 Jun;55(6):1379-82. doi: 10.1097/00007890-199306000-00032.
Bovine corneal protein (BCP) 54 is the major soluble protein of the cornea. Immune responses against this protein can be observed in patients with corneal disease or inflammatory disease of the anterior chamber of the eye. We wanted to determine whether an immune response against this corneal protein plays a role in corneal transplantation. A cell-mediated immune response against BCP 54 was therefore determined in 46 patients prior to and on several occasions during the first year following corneal transplantation. The presence of an anti-BCP 54 response before transplantation was not associated with any clinical parameters or with rejection following transplantation. The highest frequency of positive responses was observed three months after transplantation. Transplantation may have stimulated a temporary immune response against a previously sequestered antigen, but this tissue-specific immune response did not necessarily lead to rejection. Therefore, no prognostic value can be attributed to the anti-BCP 54 response.
牛角膜蛋白（BCP）54是角膜的主要可溶性蛋白。在患有角膜疾病或眼前房炎症性疾病的患者中可观察到针对该蛋白的免疫反应。我们想确定针对这种角膜蛋白的免疫反应是否在角膜移植中起作用。因此，在46例角膜移植患者术前及术后第一年的多个时间点测定了针对BCP 54的细胞介导免疫反应。移植前抗BCP 54反应的存在与任何临床参数或移植后排斥反应均无关联。移植后三个月观察到阳性反应的频率最高。移植可能刺激了针对先前隔离抗原的暂时性免疫反应，但这种组织特异性免疫反应不一定导致排斥反应。因此，抗BCP 54反应没有预后价值。
