Dillon N, Grosveld F
Laboratory of Gene Structure and Expression, MRC National Institute for Medical Research, Mill Hill, London, UK.
Trends Genet. 1993 Apr;9(4):134-7. doi: 10.1016/0168-9525(93)90208-y.
Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.
最近的研究表明,多基因位点内存在不同水平的调控机制。除了紧邻基因的调控序列外,还有一些元件能在远距离作用于多个基因。基因之间对这些元件的竞争会影响发育过程中基因表达的水平和时间。