Monaco A P
New England Deaconess Hospital, Boston, Massachusetts 02215.
Transplant Proc. 1993 Jun;25(3):2234-6.
The above studies strongly emphasize that transplantation of islets using immunoisolation with hollow fiber semipermeable immunoexclusion membranes is possible. Experiments in diabetic dogs have demonstrated that both the intravascular perfusion configured device and the intraperitoneal diffusion device could be applied clinically. Future experiments must be directed toward increasing device output, extending islet viability, and utilizing islet xenografts in both perfusion and diffusion devices in large animals prior to clinical trials.
上述研究强烈强调，使用中空纤维半透性免疫排斥膜进行免疫隔离来移植胰岛是可行的。在糖尿病犬身上进行的实验表明，血管内灌注配置装置和腹腔内扩散装置都可应用于临床。未来的实验必须致力于提高装置的产出、延长胰岛的存活期，并在临床试验之前在大型动物的灌注和扩散装置中利用胰岛异种移植。
