脂质包裹微泡超声造影剂在肿瘤治疗中的应用

Applications of lipid-coated microbubble ultrasonic contrast to tumor therapy.

作者信息

Simon R H, Ho S Y, Lange S C, Uphoff D F, D'Arrigo J S

机构信息

University of Connecticut Health Center, Department of Surgery, Farmington 06030-3955.

出版信息

Ultrasound Med Biol. 1993;19(2):123-5. doi: 10.1016/0301-5629(93)90004-8.

DOI:10.1016/0301-5629(93)90004-8

PMID:8516958

Abstract

Lipid-coated microbubbles (LCM) make an excellent diagnostic ultrasonic contrast agent in experimental tumor systems. LCM have been shown to aggregate in brain tumors and subcutaneous tumors after intravenous administration, and to provide persistent image enhancement for many minutes. In this work, experimental subcutaneous Walker Carcinosarcoma is insonated after the bubbles are given intravenously. Selective necrosis, lymphocyte proliferation and hemorrhage within the tumor can be demonstrated. Preliminary data are given to demonstrate this phenomenon. The mechanism of the effect is discussed in the context of both heating and cavitation.

摘要

脂质包被微泡（LCM）在实验性肿瘤系统中是一种出色的诊断性超声造影剂。静脉注射后，LCM已被证明会在脑肿瘤和皮下肿瘤中聚集，并能提供持续数分钟的图像增强效果。在这项研究中，静脉注射气泡后对实验性皮下沃克癌肉瘤进行超声照射。可以观察到肿瘤内出现选择性坏死、淋巴细胞增殖和出血。文中给出了初步数据以证明这一现象。并在热效应和空化效应的背景下讨论了该效应的机制。