Sasaki K, Yumita N, Nishigaki R, Umemura S
Central Research Laboratory, Hitachi, Ltd., Tokyo.
Jpn J Cancer Res. 1998 Apr;89(4):452-6. doi: 10.1111/j.1349-7006.1998.tb00584.x.
The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower, no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.
研究了聚焦超声联合镓卟啉配合物7,12-双（1-癸氧基乙基）-Ga（III）-3,8,13,17-四甲基卟啉-2,18-二丙酰天冬氨酸（ATX-70）对实验性小鼠肿瘤生长的抗肿瘤作用。将植入大鼠肾脏的Walker 256肿瘤在给大鼠注射ATX-70后，于500 kHz的连续波场中暴露于聚焦超声5分钟，同时叠加二次谐波（1 MHz）。当ATX-70剂量不少于2.5 mg/kg且焦斑平均声强为12 W/cm2或更高时，可获得显著的抗肿瘤效果。当声强为8 W/cm2或更低时，即使ATX-70剂量为2.5 mg/kg，也未观察到显著效果。同样，当ATX-70剂量为1.0 mg/kg或更低时，即使焦斑平均声强为40 W/cm2，也未观察到显著效果。
