利用磁共振成像对胼胝体进行形态测量分析：健康个体中测量值与衰老的相关性
Morphometric analysis of the corpus callosum using MR: correlation of measurements with aging in healthy individuals.
作者信息
Weis S, Kimbacher M, Wenger E, Neuhold A
机构信息
Institute of Neuropathology, University of Munich, Germany.
出版信息
AJNR Am J Neuroradiol. 1993 May-Jun;14(3):637-45.
PURPOSE
To analyze changes of the human corpus callosum and MR midsagittal brain structures during normal aging.
METHODS
A morphometric evaluation strategy for quantification of these brain structures on MR scans was developed. This computerized measuring program did allow the acquisition of more than 100 one- and two-dimensional parameters.
RESULTS
During normal aging, the anterior parts of the corpus callosum (genu and anterior parts of the trunk) were significantly decreased, suggesting alterations of frontal and temporal interhemispheric fiber systems. Further changes were seen in callosal thickness and callosal width of the anterior parts of the corpus callosum. The profile area of the telencephalon was significantly reduced during normal aging. The size of the mesencephalon showed age-specific changes.
CONCLUSIONS
The proposed computer program proved to be a powerful and reliable tool to get objective and reproducible quantitative data of corpus callosum and midsagittal brain structures. Specific age changes were found in the corpus callosum, indicating alteration of the frontotemporal interhemispheric fiber systems.
目的
分析正常衰老过程中人类胼胝体和磁共振矢状位脑结构的变化。
方法
开发了一种用于在磁共振扫描上对这些脑结构进行量化的形态测量评估策略。这种计算机化测量程序确实能够获取100多个一维和二维参数。
结果
在正常衰老过程中，胼胝体的前部（膝部和胼胝体干的前部）显著减小，提示额叶和颞叶半球间纤维系统发生改变。胼胝体前部的厚度和宽度也出现了进一步变化。在正常衰老过程中，端脑的轮廓面积显著减小。中脑的大小呈现出特定年龄的变化。
结论
所提出的计算机程序被证明是一种强大且可靠的工具，可用于获取胼胝体和矢状位脑结构的客观且可重复的定量数据。在胼胝体中发现了特定的年龄变化，表明额颞半球间纤维系统发生了改变。
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