Ghodse A H
Br Med J. 1977 Mar 26;1(6064):805-8. doi: 10.1136/bmj.1.6064.805.
During a prospective study of the whole spectrum of drug-related problems treated in one month by 62 casualty departments in the Greater London area, 949 cases of deliberate self-poisoning were identified. Nearly three-quarters of the patients were under the age of 40 years and in all age groups women outnumbered men. Psychoactive drugs of some sort were used in 673 incidents (71%) and ordinary analgesics and other drugs were used in 252 (27%). The incidence of polydrug overdose (423; 45%) was much higher than that found in other studies. In at least 256 incidents (27%) there was a history of repeated overdose in the previous 12 months. Comparison with other studies showed a steady decline in the use of barbiturates in deliberate self-poisoning but an increase in the use of non-barbiturate hypnotics, minor tranquilisers, and antidepressants.
在一项对大伦敦地区62个急诊科一个月内治疗的各类药物相关问题进行的前瞻性研究中，共识别出949例蓄意自我中毒病例。近四分之三的患者年龄在40岁以下，各年龄组中女性人数均多于男性。673起事件（71%）使用了某种精神活性药物，252起事件（27%）使用了普通镇痛药和其他药物。多药过量的发生率（423例；45%）远高于其他研究中的发现。至少256起事件（27%）中，患者在过去12个月内有多次过量用药史。与其他研究相比，蓄意自我中毒中巴比妥类药物的使用呈稳步下降趋势，但非巴比妥类催眠药、小剂量镇静剂和抗抑郁药的使用有所增加。
