Bakken J S, Cavalieri S J, Gangeness D, Kubat T, Pollack J R
Duluth Clinic, Ltd., Minnesota.
Antimicrob Agents Chemother. 1993 May;37(5):1171-3. doi: 10.1128/AAC.37.5.1171.
To study the plasma elimination rate of ceftriaxone given to patients undergoing plasmapheresis, a single 2-g intravenous dose of ceftriaxone was given to 11 patients who underwent plasmapheresis 3 h (early group) or 15 h (late group) later. Even though the early patient group had twofold more ceftriaxone removed than the late group, all individual patients had 24-h ceftriaxone levels of 9 micrograms/ml or higher. We conclude that patients undergoing plasmapheresis lasting 150 min or less may safely be treated with 2 g of ceftriaxone once daily without risking periods of subtherapeutic plasma ceftriaxone levels.
为研究接受血浆置换的患者头孢曲松的血浆清除率，对11例接受血浆置换的患者静脉注射单剂量2克头孢曲松，分别于3小时（早期组）或15小时（晚期组）后进行血浆置换。尽管早期患者组头孢曲松的清除量是晚期组的两倍，但所有个体患者24小时头孢曲松水平均达到9微克/毫升或更高。我们得出结论，接受持续150分钟或更短时间血浆置换的患者，每天一次给予2克头孢曲松治疗是安全的，不会有血浆头孢曲松水平低于治疗浓度的风险。
