Naganuma Y, Konishi T, Hongou K, Murakami M, Yamatani M, Okada T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
No To Hattatsu. 1993 May;25(3):227-32.
Auditory event-related potentials (ERPs) were recorded from 131 epileptic children of 4 to 20 years of age, and the related factors affecting P300 latencies were evaluated using multiple regression analysis. The examined factors were as follows: (1) age at P300 recording and duration of illness, (2) seizure types and epileptic syndromes, (3) anti-epileptic drugs (AEDs), (4) seizure prognosis, (5) organic brain dysfunctions, (6) x-ray CT and (7) EEG background activity and frequency of paroxysms. ERPs were elicited with the oddball paradigm. Five factors of them had significant correlations with P300 latencies. 1) P300 latencies were gradually shortened with age. 2) P300 latencies were prolonged in the patients before and during AED medication compared with those during the period of off-therapy. 3) Symptomatic partial epilepsy showed obviously prolonged P300 latencies. 4) P300 latencies were shortened with increasing alpha 2 power of EEG. 5) P300 latencies became prolonged with the length of illness.
对131名4至20岁的癫痫儿童进行了听觉事件相关电位（ERP）记录，并使用多元回归分析评估了影响P300潜伏期的相关因素。所检查的因素如下：（1）P300记录时的年龄和病程，（2）癫痫发作类型和癫痫综合征，（3）抗癫痫药物（AEDs），（4）癫痫发作预后，（5）器质性脑功能障碍，（6）X线CT以及（7）脑电图背景活动和发作频率。采用oddball范式诱发ERP。其中五个因素与P300潜伏期有显著相关性。1）P300潜伏期随年龄逐渐缩短。2）与停药期相比，服用AED药物前和服药期间患者的P300潜伏期延长。3）症状性部分性癫痫的P300潜伏期明显延长。4）P300潜伏期随着脑电图α2功率的增加而缩短。5）P300潜伏期随着病程延长而延长。
