Mattsson L A, Samsioe G, von Schoultz B, Uvebrant M, Wiklund I
Department of Obstetrics and Gynecology, Ostra Hospital, University of Göteborg, Sweden.
Br J Obstet Gynaecol. 1993 May;100(5):450-3. doi: 10.1111/j.1471-0528.1993.tb15270.x.
To investigate the effects of two doses of transdermally applied oestradiol on lipid and lipoprotein metabolism in climacteric women.
A randomised double blind cross-over comparison.
Departments of Obstetrics and Gynaecology, Ostra and Sahlgren's Hospital, Göteborg and Karolinska Hospital, Stockholm, Sweden.
Fifty-two women with climacteric symptoms were treated with oestradiol transdermally applied (50 micrograms and 100 micrograms/24 h). A daily dose of 5 mg oral medroxyprogesterone acetate was added 14 days each treatment cycle of four weeks.
Blood samples were drawn after an overnight fast before and after four and eight months of treatment.
Assays for serum triglycerides and cholesterol as well as low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol including the subfractions HDL2 and HDL3 were performed.
Significant decrements were found in triglycerides and serum and LDL cholesterol during treatment with both doses. A modest rise in HDL2 cholesterol was observed after treatment with the 100 micrograms/24 h dose.
The serum lipid and lipoprotein profile encountered in these women was similar to that reported with oral formulations except for a decrease in triglycerides. The metabolic differences between the two doses of transdermal oestradiol is probably of minor clinical significance in normal postmenopausal women.
研究两种剂量经皮应用雌二醇对更年期女性脂质及脂蛋白代谢的影响。
随机双盲交叉对照试验。
瑞典哥德堡的厄斯特拉和萨尔格伦医院妇产科以及斯德哥尔摩的卡罗林斯卡医院。
52名有更年期症状的女性接受经皮应用雌二醇治疗（50微克和100微克/24小时）。在为期四周的每个治疗周期中，每14天添加每日剂量5毫克的口服醋酸甲羟孕酮。
在治疗前、治疗四个月和八个月后，空腹过夜后采集血样。
检测血清甘油三酯、胆固醇以及低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇，包括HDL2和HDL3亚组分。
两种剂量治疗期间甘油三酯、血清和LDL胆固醇均显著下降。100微克/24小时剂量治疗后，HDL2胆固醇略有升高。
这些女性的血清脂质和脂蛋白谱与口服制剂报道的相似，但甘油三酯有所下降。两种剂量经皮雌二醇之间的代谢差异在正常绝经后女性中可能临床意义不大。
