Emery E F, Greenough A
Department of Child Health, King's College Hospital, London, UK.
Acta Paediatr. 1993 May;82(5):430-2. doi: 10.1111/j.1651-2227.1993.tb12716.x.
Urine output following administration of a low-dose dopamine infusion was assessed in 20 very immature infants (median gestational age 27 weeks). Prior to the infusion, all infants had had a period of anuria. Urine output improved significantly during the second 24 h after commencing the infusion but, at that time period, urine output was greater than 2 ml/kg/h (designated a good response) in only 13 infants. There was no significant difference in gestational age, birth weight, period of anuria or fluid input of infants who had a good or a poor response to dopamine. Although the baseline blood pressure did not differ significantly between these two groups, the increase in blood pressure resulting from dopamine administration was significantly greater in those infants with a good response in urine output (p < 0.02). We conclude that low-dose dopamine infusion can improve urine output in very immature infants. Our results suggest that there may be inter-individual variation in the sensitivity to dopamine.
对20名极不成熟的婴儿（中位胎龄27周）进行了低剂量多巴胺输注后尿量的评估。在输注前，所有婴儿均有一段无尿期。开始输注后的第二个24小时内尿量显著改善，但在该时间段，只有13名婴儿的尿量大于2 ml/kg/h（定义为良好反应）。对多巴胺反应良好或不佳的婴儿在胎龄、出生体重、无尿期或液体输入方面无显著差异。尽管两组之间的基线血压无显著差异，但尿量反应良好的婴儿因多巴胺给药导致的血压升高显著更大（p < 0.02）。我们得出结论，低剂量多巴胺输注可改善极不成熟婴儿的尿量。我们的结果表明，对多巴胺的敏感性可能存在个体差异。
