Boersma C J, Sonnemans M A, Van Leeuwen F W
Netherlands Institute for Brain Research, Amsterdam.
Brain Res. 1993 May 14;611(1):117-29. doi: 10.1016/0006-8993(93)91783-o.
A pre-embedding immunoelectron microscopic technique was used to obtain morphological evidence for a role of oxytocin and vasopressin in the regulation of their own or each others release from the neural lobe. No synaptoid contacts of oxytocin- or vasopressin-containing axons with other neuronal structures were observed. However, synaptoid contacts of oxytocin- and vasopressin-containing nerve terminals and Herring bodies with pituicytes were frequently observed. These findings suggest that the pituicyte may participate in auto- and/or cross-regulation of oxytocin and vasopressin release. Moreover, oxytocin and vasopressin precursor-derived peptides were found in the cytoplasm of some pituicytes, an unexpected finding that will be discussed.
采用预包埋免疫电子显微镜技术，以获取催产素和血管加压素在调节其自身或彼此从神经叶释放过程中发挥作用的形态学证据。未观察到含催产素或血管加压素的轴突与其他神经元结构之间的突触样接触。然而，经常观察到含催产素和血管加压素的神经末梢及赫林体与垂体细胞之间的突触样接触。这些发现表明，垂体细胞可能参与催产素和血管加压素释放的自身调节和/或交叉调节。此外，在一些垂体细胞的细胞质中发现了催产素和血管加压素前体衍生肽，这一意外发现将予以讨论。
