Adams N
Department of Social Sciences, Winston-Salem State University, NC 27110, USA.
Alcohol. 1995 Sep-Oct;12(5):463-8. doi: 10.1016/0741-8329(95)00032-m.
Voluntary consumption of 10% ethanol (EtOH) vs. water was compared in EtOH-naive, male and female Maudsley Reactive (MR) inbred rats that were exposed to either daily episodes of tail pinch (TP), or no-stress controls for 35 consecutive days. Females drank significantly more EtOH than males as measured by preference for 10% EtOH vs. water, and for intake of pure EtOH. Females exposed to TP had a higher preference for EtOH relative to controls after 21 days, but there was no difference over the entire 35 days. Males exposed to TP tended to drink more EtOH during the last week of testing relative to controls. Experiment 2 compared MR females with Maudsley Nonreactive (MNRA) females for 3 weeks in the conditions described above; TP exposure increased EtOH preference in MR, but not in MNRA, females. MR females also consumed significantly more EtOH than MNRA females. In both experiments female rats drank amounts of EtOH following a 6-week period of EtOH abstinence comparable to their preabstinence levels. The large degree of variability found in inbred MR rats has implications for developing a model for the investigation of environmental influences on the development of EtOH abuse in genetically susceptible individuals.
在未接触过乙醇的雄性和雌性莫兹利反应性（MR）近交系大鼠中，比较了自愿饮用10%乙醇（EtOH）与水的情况。这些大鼠连续35天每天接受尾部夹捏（TP）刺激或作为无应激对照。通过对10%乙醇与水的偏好以及纯乙醇的摄入量测量发现，雌性大鼠饮用的乙醇显著多于雄性大鼠。暴露于TP刺激的雌性大鼠在21天后相对于对照组对乙醇的偏好更高，但在整个35天期间没有差异。暴露于TP刺激的雄性大鼠在测试的最后一周相对于对照组倾向于饮用更多的乙醇。实验2在上述条件下将MR雌性大鼠与莫兹利非反应性（MNRA）雌性大鼠进行了3周的比较；TP刺激增加了MR雌性大鼠对乙醇的偏好，但对MNRA雌性大鼠没有影响。MR雌性大鼠饮用的乙醇也显著多于MNRA雌性大鼠。在两个实验中，雌性大鼠在戒酒6周后的乙醇摄入量与戒酒前水平相当。在近交系MR大鼠中发现的高度变异性对建立一个模型来研究环境对遗传易感个体乙醇滥用发展的影响具有启示意义。
