Demers L M, Allegra J C, Harvey H A, Lipton A, Luderer J R, Mortel R, Brenner D E
Cancer. 1977 Apr;39(4):1559-62. doi: 10.1002/1097-0142(197704)39:4<1559::aid-cncr2820390430>3.0.co;2-3.
Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy.
对79例实体肿瘤患者进行了外周血浆前列腺素E（PGE）测定，并将其与血清钙水平进行了关联分析。14例患者出现高钙血症，其中11例循环血浆PGE显著升高。高钙血症组中有10例发生广泛骨转移。这些发现支持了最近提出的假说，即前列腺素与恶性肿瘤高钙血症的发生存在因果关系。
