Hanski C
Universitätsklinikum Benjamin Franklin, Department of Gastroenterology, Freie Universität Berlin, Germany.
Br J Cancer. 1995 Dec;72(6):1350-6. doi: 10.1038/bjc.1995.514.
Mucinous carcinomas are defined on the basis of the amount of the mucus component in the tumour mass. Apart from this quantitative criterion, a number of clinicopathological parameters (such as localisation, prevalence in different countries and age groups, association with HNPCC and inflammatory processes) and genetic alterations (e.g. frequency of mutation in Ki-ras and p53 genes, level of MUC2 expression) differentiate these tumours from the non-mucinous ones. Since a different set of genetic lesions implies different inducing agents, these observations suggest that there may be a 'mucinous pathway of carcinogenesis'. Further identification of genetic changes characteristic of the mucinous phenotype will help to understand the aetiology of these tumours and possibly establish markers for detection of the high-risk group.
黏液腺癌是根据肿瘤块中黏液成分的含量来定义的。除了这一量化标准外，一些临床病理参数（如定位、在不同国家和年龄组中的患病率、与遗传性非息肉病性结直肠癌及炎症过程的关联）和基因改变（如Ki-ras和p53基因的突变频率、MUC2表达水平）将这些肿瘤与非黏液性肿瘤区分开来。由于一组不同的基因损伤意味着不同的诱导因素，这些观察结果表明可能存在一条“黏液性致癌途径”。进一步鉴定黏液性表型特有的基因变化将有助于了解这些肿瘤的病因，并有可能建立用于检测高危人群的标志物。
