Albagli O, Dhordain P, Deweindt C, Lecocq G, Leprince D
Institut National de la Santé et de la Recherche Médicale U124-IRCL, Lille, France.
Cell Growth Differ. 1995 Sep;6(9):1193-8.
The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chromatin folding.
BTB/POZ结构域定义了一个新发现的蛋白质-蛋白质相互作用界面。它在整个后生动物进化过程中高度保守，通常位于肌动蛋白结合蛋白（更常见的是核DNA结合蛋白）的NH2末端。通过介导大聚合体中的蛋白质结合，BTB/POZ结构域有助于组织参与环管形成或染色质折叠的高阶大分子复合物。
