Fine S R, Lodha A, Zoneraich S, Mollura J L
Division of Allergy and Immunology, Albert Einstein College of Medicine, Flushing Hospital Medical Center, NY 11355, USA.
Ann Pharmacother. 1995 Jul-Aug;29(7-8):701-3. doi: 10.1177/106002809502907-809.
To describe a patient with noncardiogenic acute pulmonary edema induced by hydrochlorothiazide.
A 70-year-old woman in generally good health, except for mild pedal edema, developed acute pulmonary edema after ingesting hydrochlorothiazide 12.5 mg for the first time.
This is the fifteenth reported case of noncardiogenic pulmonary edema induced by hydrochlorothiazide. The investigations by previous authors seemed to rule out an immunologic mechanism; thus, the pathogenesis of the reaction is unknown. Most of the reactions have occurred in women.
Noncardiogenic pulmonary edema appears to be an idiosyncratic reaction that occurs with some specificity with the thiazide diuretics. Clinicians should be aware of this potential, serious adverse reaction that occurs without warning.
描述一例由氢氯噻嗪引起的非心源性急性肺水肿患者。
一名70岁女性，总体健康状况良好，仅有轻度足背水肿，首次服用12.5毫克氢氯噻嗪后发生急性肺水肿。
这是第15例报道的由氢氯噻嗪引起的非心源性肺水肿病例。既往作者的研究似乎排除了免疫机制；因此，该反应的发病机制尚不清楚。大多数反应发生在女性身上。
非心源性肺水肿似乎是一种特异反应，在噻嗪类利尿剂使用中具有一定特异性。临床医生应意识到这种无预警发生的潜在严重不良反应。
