Pruekprasert P, Stout C, Patamasucon P
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Thailand.
J Assoc Acad Minor Phys. 1995;6(4):134-8.
A neonate who had a nonfatal echovirus 11 infection with severe hepatitis, hepatic necrosis, disseminated intravascular coagulation, and thrombocytopenia was seen at the University of Tennessee Medical Center (UTMC) in Knoxville. Clinical data from this neonate were examined and compared with clinical data from histories of 8 other cases of neonatal enteroviral infections seen at UTMC, Knoxville, during a 3-year period. The purpose of our study was to increase awareness of the clinical presentations of neonatal enteroviral infections, especially in summer months. The patients in our study presented with various clinical manifestations of disease, including overwhelming systemic infection characterized by severe hepatic dysfunction and coagulopathy with possible disseminated intravascular coagulation and central nervous system infection. Myocarditis was sometimes manifested as well. In agreement with findings from other studies, our study concluded that most enteroviral infections in neonates resulted from perinatal transmission during delivery where the mothers had experienced recent, febrile, viral-like illness prior to or during delivery. One uncommon finding in our study was that the cases were strikingly seasonal, with 8 of the 9 infants hospitalized during late summer or early fall (July through September).
田纳西大学医学中心（UTMC）位于诺克斯维尔，收治了一名感染11型艾柯病毒的新生儿，该感染导致严重肝炎、肝坏死、弥散性血管内凝血和血小板减少，但未致命。我们对该新生儿的临床数据进行了检查，并与田纳西大学医学中心（UTMC）诺克斯维尔分院在3年期间收治的其他8例新生儿肠道病毒感染病例的病史临床数据进行了比较。我们研究的目的是提高对新生儿肠道病毒感染临床表现的认识，尤其是在夏季。我们研究中的患者表现出各种疾病临床表现，包括以严重肝功能障碍和凝血病为特征的严重全身感染，可能伴有弥散性血管内凝血和中枢神经系统感染。有时也会表现出心肌炎。与其他研究结果一致，我们的研究得出结论，新生儿的大多数肠道病毒感染是由分娩期间的围产期传播引起的，母亲在分娩前或分娩期间曾经历近期发热的类似病毒疾病。我们研究中一个不常见的发现是，这些病例具有明显的季节性，9名婴儿中有8名在夏末或初秋（7月至9月）住院。
