精子刺激剂在接受体外受精的男性因素病例中可提高受精率，其程度与通过部分透明带切割（PZD）或透明带下精子注射（SUZI）进行的显微操作相同：一项随机对照研究。
Sperm stimulants can improve fertilization rates in male-factor cases undergoing IVF to the same extent as micromanipulation by partial zona dissection (PZD) or subzonal sperm insemination (SUZI): a randomized controlled study.
作者信息
Edirisinghe W R, Junk S, Yovich J M, Bootsma B, Yovich J L
机构信息
PIVET Medical Centre, Leederville, Perth, Western Australia.
出版信息
J Assist Reprod Genet. 1995 May;12(5):312-8. doi: 10.1007/BF02213710.
PURPOSE
Our purpose was to evaluate the efficacy of direct insemination (IVF), micromanipulation by partial zona dissection (PZD), and subzonal sperm insemination (SUZI) using sperm-treated with pentoxifylline (PF) +/- 2-deoxyadenosine (2DA).
RESULTS
The overall fertilization rate achieved was similar for all three fertilization techniques (33.1, 30.2, and 26.9% for IVF, SUZI, and PZD, respectively). Patients who had reduced fertilization in previous IVF attempts showed improved fertilization with sperm stimulants, either PF alone or PF in combination with 2DA in standard IVF. In certain cases, SUZI or PZD gave significantly improved fertilization rates in comparison to IVF.
CONCLUSION
Selective use of sperm stimulants in IVF can achieve fertilization for the majority of male-factor cases. However, PZD and SUZI techniques are useful, especially when sperm stimulants fail to achieve fertilization or achieve poor fertilization in direct insemination.
目的
我们的目的是评估使用经己酮可可碱（PF）+/- 2-脱氧腺苷（2DA）处理的精子进行直接授精（体外受精，IVF）、部分透明带切割显微操作（PZD）和透明带下精子注射（SUZI）的效果。
结果
三种受精技术的总体受精率相似（IVF、SUZI和PZD分别为33.1%、30.2%和26.9%）。在之前的IVF尝试中受精率降低的患者，使用精子刺激剂后受精情况有所改善，在标准IVF中单独使用PF或PF与2DA联合使用。在某些情况下，与IVF相比，SUZI或PZD的受精率显著提高。
结论
在IVF中选择性使用精子刺激剂可使大多数男性因素导致的病例实现受精。然而，PZD和SUZI技术很有用，特别是当精子刺激剂在直接授精中未能实现受精或受精不良时。
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